BIOPHARMACEUTICS BY BRAHMANKAR PDF

You are on page 1of Search inside document 1 Introduction Drugs, whether obtained from plant, animal or mineral sources or synthesized chemically, are rarely administered in their pure chemical form. Earlier, it was believed that the therapeutic response to a drug is an attribute of its intrinsic pharmacological activity. But today, it is very much understood that the dose-response relationship obtained after drug administration by different routes—for example, oral and parenteral, are not the same. Variations are also observed when the same drug is administered as different dosage forms or similar dosage forms produced by different manufacturers, which in turn depend upon the physicochemical properties of the drug, the excipients present in the dosage form, the method of formulation and the manner of administration. A new and separate discipline called biopharmaceutics has therefore been developed to account for all such factors that influence the therapeutic effectiveness of a drug.

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The main aim of this blog is to help pharma students and professionals in field of pharmacy and pharmabiotechnology. Friday, September 30, Biopharmaceutics and Pharmacokinetics A Treatise by Brahmankar D M, Jaiswal S B 30th September Tuesday PM Banaras Hi friends this book covers the twin disciplines of Biopharmaceutics and Pharmacokinetics have, therefore, been developed with the objective of learning how drugs can be utilized optimally in the treatment of diseases—through design and development of new and better therapeutic moieties, new dosage forms and appropriate dosage regimens.

A very good book for undergraduate students of pharmacy. Significant expansion of the chapter on controlled release medication has been made to cover in a broader perspective, the principles employed in the design of such dosage forms, their classification and brief description of the technologies and products delivered by various routes.

The concerted attempt was to collectively address the several modern approaches adopted to design the modified drug delivery systems, which is an exciting and highly dynamic area of pharmaceutical research. Significant advances in the understanding of diseases have necessitated the need to optimize drug therapy. The concern today is not just to produce elegant and accurate dosage forms but also to ensure that optimum amount of drug reaches the target site at an optimal rate and its concentration is maintained for the entire duration of therapy.

A thorough background of the fate of drug after its administration; the rate processes to which it is subjected in the body and its behavior after biotransformation, are thus very essential in addition to the knowledge about its pharmacodynamics. The chapter on Absorption of Drugs has been dealt with comprehensively as most of its principles also form the basis of drug distribution and elimination.

Elaborate treatment of text on Biotransformation of Drugs in chapter 5 is justified since a pharmacy student is well versed with the basic chemistry and enzymology. A brief mention about Bioactivation and Tissue Toxicity has been included at the end of this chapter so that after understanding the mechanisms of drug metabolism, a student will be better placed to appreciate their significance. Prodrugs discussed in chapter 6 give insight into the manner in which chemical formulation techniques can be utilized to overcome some of the inherent biopharmaceutic and pharmacokinetic problems of the active principles.

Mathematical treatment of chapters on pharmacokinetics has been kept to at modest level in order not to overburden the students with the complexities of equations and formulae.

A brief description of methods usually employed to enhance the bioavailability of a drug from its formulation has been included. In addition to covering various aspects of design of dosage regimens and application of pharmacokinetic principles in clinical situations, the text contains a chapter on Controlled Release Medication to familiarize the students with the principles involved in the design of innovative formulations.

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The main aim of this blog is to help pharma students and professionals in field of pharmacy and pharmabiotechnology. Friday, September 30, Biopharmaceutics and Pharmacokinetics A Treatise by Brahmankar D M, Jaiswal S B 30th September Tuesday PM Banaras Hi friends this book covers the twin disciplines of Biopharmaceutics and Pharmacokinetics have, therefore, been developed with the objective of learning how drugs can be utilized optimally in the treatment of diseases—through design and development of new and better therapeutic moieties, new dosage forms and appropriate dosage regimens. A very good book for undergraduate students of pharmacy. Significant expansion of the chapter on controlled release medication has been made to cover in a broader perspective, the principles employed in the design of such dosage forms, their classification and brief description of the technologies and products delivered by various routes. The concerted attempt was to collectively address the several modern approaches adopted to design the modified drug delivery systems, which is an exciting and highly dynamic area of pharmaceutical research. Significant advances in the understanding of diseases have necessitated the need to optimize drug therapy. The concern today is not just to produce elegant and accurate dosage forms but also to ensure that optimum amount of drug reaches the target site at an optimal rate and its concentration is maintained for the entire duration of therapy.

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