If a 1-hour infusion is used, Cmax occurs when the infusion is completed. Aminoglycosides have a post-antibiotic effect. They inhibit bacterial growth even after drug concentrations decrease to undetectable levels. Nomograms Hartford Nomogram One of the first published extended interval nomograms
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If a 1-hour infusion is used, Cmax occurs when the infusion is completed. Aminoglycosides have a post-antibiotic effect. They inhibit bacterial growth even after drug concentrations decrease to undetectable levels. Nomograms Hartford Nomogram One of the first published extended interval nomograms This results in higher peak levels which may be beneficial for hospitals with higher average MICs to gentamicin or tobramycin. Includes a hour dosing interval for patients with very fast clearance.
Dosage calculations The same method is used for calculating dosing weight for the Hartford and Urban-Craig nomograms: IBW is used to calculate doses for non-obese patients. Determining the dosing interval Check a random level 6- 14 hours after the first dose, and plot the result on the nomogram to determine the dosing interval.
If the result is on the line, the longer interval is chosen to avoid drug accumulation and provide a sufficient drug-free period. Consider re-checking a random level after the second dose to confirm the dosing interval, and then re-check a random level and SCr about every 2- 3 days. Occurs 60 minutes after the start of infusion. Occurs just prior the next dose.
Aminoglycoside Initial Dosing – Traditional Method
Taking what could be a very difficult and "science-y" topic and breaking it down to an easy to digest page-turner. We thank Steph for writing it, and we hope you enjoy it. So, first point Aminoglycosides are bacterial protein synthesis inhibitors. And they do this by binding to the 30S and 50S subunits of bacterial ribosomes. Remember that ribosomes are responsible for translation of mRNA into strings of amino acids.
Gram positive synergy Enterococcal endocarditis Extended-Interval Nomograms This calculator uses four extended-interval nomograms. You may select a specific nomogram by clicking the "Config" icon in the top, right-hand corner of this webpage. Hartford Nomogram 3 The Hartford nomogram was one of the first published extended-interval nomograms. Although this higher dose has not been shown to improve clinical outcomes, it may be beneficial for institutions with higher average MICs to gentamicin or tobramycin.